Title Anses calls for new in vitro genotoxicity tests for titanium dioxide
Source Other
Date 2018-05-17 PM 3:45:02 Hit 160
There is an urgent need for new and improved in vitro genotoxicity tests for titanium dioxide nanoparticles (NPs), according to the French Agency for Food, Environment and Occupational Health and Safety (Anses).
While collecting carcinogenicity information for hazard assessment of titanium dioxide, Anses found that few in vivo studies were good enough to reach a conclusion on genotoxicity. "The low quality of the in vivo dataset is likely to lead to possible false interpretation of the genotoxic profile of titanium dioxide NPs," according to a report written by a team from the agency's chemical assessment unit.
"Even if in vivo data are considered of higher relevance than in vitro data, unfortunately they are too limited to conclude on genotoxicity of titanium dioxide NPs," it writes in Nanotoxicology.
Numerous in vitro studies are available, but these also give an inconsistent genotoxicity profile, it adds.
Titanium dioxide was added to the Community Rolling Action Plan (Corap) in 2013, but its evaluation has been dogged by issues regarding the identity - the shape, size and coating - of different types of nanomaterials. The difficulties are exacerbated by the myriad uses of the substance.
France updated its Corap justification document in March 2018, stating that "in the absence of reliable in vivo assays, there is an essential need for further in vitro and in vivo investigations of the genotoxicity potential of titanium dioxide NPs".


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